A Mesoscopic Approach to Model Regulation of Apoptosis by P53
Abstract
A mechanism to describe the apoptosis process at mesoscopic level through p53 is proposed in this paper. A deterministic model given by three differential equations is deduced from the mesoscopic approach, which exhibits sustained oscillations caused by a supercritical Andronov-Hopf bifurcation. Taking as hypothesis that the p53 sustained oscillation is the fundamental mechanism for apoptosis regulation; the model predicts that it is necessary a strict control of p53 to stimulated it, which is an important consideration to established new therapy strategy to fight cancer.
Published
Dec 15, 2011
How to Cite
IZQUIERDO-KULICH, Elena; NIETO-VILLAR, José Manuel.
A Mesoscopic Approach to Model Regulation of Apoptosis by P53.
Revista Cubana de Física, [S.l.], v. 28, n. 2, p. 119-122, dec. 2011.
ISSN 2224-7939.
Available at: <https://revistacubanadefisica.org/index.php/rcf/article/view/RCF_28-2_119_2011>. Date accessed: 18 apr. 2024.
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Section
Original Articles
This work is licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license.