Intrinsic Noise Effect in the dynamics of p53-Mdm2 Module

Abstract

The p53 protein plays a critical role in the prevention of cancer and it is inactivated in most of human cancers. Experimental studies show that stress conditions, like DNA damage, induce oscillations in the concentrations of the proteins p53 and in its main negative regulator, Mdm2. In this work we studied a model capable of reproducing these oscillations. We formulated the problem in a stochastic way and we obtained a deterministic system to describe this model. We used Gillespie's algorithm to simulate the behavior of the system, and to compare with the deterministic solution and with the experimental observations.